12/21/2023 0 Comments Mjolnir hammer![]() Far too many of them have already decided that they're not getting it, no matter what. ![]() My own take on this is that at this point many of the people who are still vaccine-hesitant probably don't need another excuse. People are already wondering if this drug is going to turn into an excuse for people not to get the vaccine. But a prophylactic drug has its own complications - how long do you need to keep taking it, and how long can you without side effects, for starters. We already know from the first molnupiravir trial results that it's not really effective in people who already have severe disease, so the earlier the better (and you don't get much earlier than not having quite caught the disease yet). Merck has another trial ongoing looking at the drug as an outright preventative, where it's being given to people who are at high risk of developing the disease due to exposure to infected patients - after these results, people will be waiting eagerly to see that readout as well. Every positive surprise in this pandemic is to be celebrated. These are stronger numbers than I expected, to be honest, given that most single-drug antiviral regimens don't reach this level of efficacy. As that earlier blog post mentioned, remdesivir recently showed that it can be useful if given in the earliest states of the disease, but since it's administered i.v., that patient population is not really available to be dosed that way! An oral pill is another matter, though. This is of great interest for several reasons, and the biggest is that this is a therapy that patients can take themselves, at home. No safety signals were observed (there were more adverse events in the control group), and initial indications are that it was similarly effective against different variants of the virus, including the now-ubiquitous Delta. Merck says that they will be applying for Emergency Use Authorization as soon as possible. These numbers - an interim analysis of everyone who had been enrolled as of August 5 - were strong enough, as mentioned, for the independent monitoring committee (which met on Tuesday) to recommend that the trial be halted. And interestingly, there were 8 deaths in the control group and none in the treatment group. Meanwhile, in the treatment group (4 doses/day of molnupiravir orally for five days), 7.3% of the patients were hospitalized (29/385). These patients had at least one known risk factor for severe disease (obese, 60 years old or older, diabetes, or heart disease), and in the standard-of-care placebo group, 14.1% of these patients (53/377) were hospitalized or died from the disease by day 29 after randomization. What data we have look quite encouraging: this study (MOVe-OUT) was done in unvaccinated at-risk patients who were newly diagonosed with the coronavirus. I'm glad to report that this prediction was wrong: the trial in early-stage coronavirus patients was stopped early due to efficacy, and the press release came out this morning! That name comes from Thor's hammer, in case you're wondering (Mjollnir), and for once one of these hype names seems to have delivered. Click on the images below to enlarge it.I wrote here recently about molnupiravir, the unusually potent small-molecule viral polymerase inhibitor that Merck has in clinical trials, and mentioned that it looked like we would only hear about its current results in November or December. Keep in mind this is a ONE HANDED weapon, most list it wrongly as a two hander, including this site at one point. When you arrive, you'll find a slightly linear trail that leads to a rocky area where you'll see Mjolnir at the end. ![]() The hammer can be found in the northernmost mountain range. When you have all 5 pieces, equip them in order to be deemed worthy and head over to Hodafylke, Norway. You must first obtain all 5 pieces of Thor's Set, the following set pieces are: Weapons can be Upgraded a number of times to further increase their damage and effectiveness using Materials found in the world. Weapons can be Enhanced at any Blacksmith to increase their quality and add Rune Slots. However, in order to wield a two-handed weapon in each hand you will need the skill: Heavy Dual Wield.Įach weapon in ACV is associated with either the Raven Skill Tree, Bear Skill Tree, or Wolf Skill Tree. Mjolnir in Assassin's Creed Valhalla is a Weapon that can be wielded in either hand, and allows the player to attack enemies effectively. Every hit has a chance to do Stun Damage to all enemies around.
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